What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial).

What question did this study set out to answer?

Evaluate the safety and efficacy of cryopreserved hematopoietic progenitor cells in HLA-mismatched allogeneic transplantation.

December 8, 2025Blood

High-dose cryopreserved bone marrow from deceased donors may reduce relapse in HLA-mismatched allogeneic transplantation: Day 180 post-transplant HOPE update

View Full Paper

Ask AI

Bookmark

Authors

JPJeremy PantinSarah Cannon

Discussion

Member takes

Implication

Clinical trial shows cryopreserved hematopoietic progenitor cells effectively prevent relapse in HLA-mismatched transplants, indicating promise for future therapies.

Key Points

Evaluate the safety and efficacy of cryopreserved hematopoietic progenitor cells in HLA-mismatched allogeneic transplantation.
Enrolled four patients with acute myeloid leukemia lacking matched donors.
Used high-dose cryopreserved CD34+ cells from deceased donors.
Administered GVHD prophylaxis including tacrolimus and mycophenolate mofetil.
Day 180 survival rate was 100% for three patients.
All patients were relapse-free with sustained cell counts at Day 180.
Managed acute GVHD cases without significant complications.

Cite This Study

Jeremy Pantin (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db3a https://doi.org/10.1182/blood-2025-5976

View Full Paper

Ask AI

Bookmark

Implication

Clinical trial shows cryopreserved hematopoietic progenitor cells effectively prevent relapse in HLA-mismatched transplants, indicating promise for future therapies.

High-dose cryopreserved bone marrow from deceased donors may reduce relapse in HLA-mismatched allogeneic transplantation: Day 180 post-transplant HOPE update

Discussion

Member takes

Implication

Key Points

Cite This Study

High-dose cryopreserved bone marrow from deceased donors may reduce relapse in HLA-mismatched allogeneic transplantation: Day 180 post-transplant HOPE update

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider