What question did this study set out to answer?

To evaluate changes in T-cell phenotype and function in patients undergoing bispecific antibody therapy.

December 8, 2025BloodOpen Access

Longitudinal analysis of T-cell phenotype and function during bispecific antibody therapy

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Authors

ADAkiva Diamond

Discussion

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Overview

Longitudinal analysis reveals T-cell dysfunction in patients with hematologic malignancies treated with bispecific antibodies, suggesting implications for tumor microenvironment.

Key Points

To evaluate changes in T-cell phenotype and function in patients undergoing bispecific antibody therapy.
Longitudinal study with patient sample collection at multiple time points
Flow cytometry analysis of T-cell phenotype and exhaustion markers
ELISPOT assays to quantify virus-specific T-cell function
Elevated PD-1 expression persisted throughout bispecific antibody treatment
Reduction in naïve and central memory T cells observed post-treatment
CMV-specific T cells were dominant in the virus-specific T-cell landscape, correlating with treatment response.

Cite This Study

Akiva Diamond (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db4b https://doi.org/10.1182/blood-2025-5346

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December 8, 2025BloodOpen Access

Longitudinal analysis of T-cell phenotype and function during bispecific antibody therapy

View Full Paper

Ask AI

Bookmark

Authors

ADAkiva Diamond

Discussion

Member takes

Overview

Longitudinal analysis reveals T-cell dysfunction in patients with hematologic malignancies treated with bispecific antibodies, suggesting implications for tumor microenvironment.

Key Points

To evaluate changes in T-cell phenotype and function in patients undergoing bispecific antibody therapy.
Longitudinal study with patient sample collection at multiple time points
Flow cytometry analysis of T-cell phenotype and exhaustion markers
ELISPOT assays to quantify virus-specific T-cell function
Elevated PD-1 expression persisted throughout bispecific antibody treatment
Reduction in naïve and central memory T cells observed post-treatment
CMV-specific T cells were dominant in the virus-specific T-cell landscape, correlating with treatment response.

Cite This Study

Akiva Diamond (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db4b https://doi.org/10.1182/blood-2025-5346

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