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December 8, 2025Blood

Frontline therapy patterns and outcomes in chronic lymphocytic leukemia: A real-world, multicenter analysis from Latin America.

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Authors

MCMaría Silvana CugliariVIVictoria IrigoinJAJose Alvarez

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Overview

Retrospective analysis shows targeted therapies improve progression-free survival in chronic lymphocytic leukemia, indicating urgent need to address suboptimal treatments.

Key Points

  • This analysis aims to compare therapy patterns and outcomes in chronic lymphocytic leukemia across multiple Latin American centers.
  • Conducted a retrospective analysis of CLL patients receiving first-line therapy in 10 Latin American countries.
  • Grouped treatment regimens into categories, including targeted therapies and chemoimmunotherapy.
  • Analyzed progression-free survival and overall survival to assess treatment impact.
  • 24.4% of patients received guideline-recommended FCR or BR regimens.
  • Progression-free survival at 3 years was 51%, with venetoclax regimens achieving 75% PFS.
  • 42.1% of patients received suboptimal therapies, indicating a significant area for improvement.

Cite This Study

Cugliari et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db71https://doi.org/10.1182/blood-2025-2775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An international view on the current approaches to frontline chronic lymphocytic leukemia therapy2025
  2. 2Baseline clinical characteristics of patients with chronic lymphocytic leukemia (CLL) from 11 Latin American countries: A real-world registry analysis2025
  3. 3Discovering the epidemiology, treatment patterns, and outcomes of chronic lymphocytic leukemia: A retrospective multicenter cohort study2025
  4. 4First-line venetoclax-based regimens versus chemoimmunotherapy in chronic lymphocytic leukemia: A real-world analysis from the brazilian CLL registry2025
  5. 5Real-world treatment and outcomes of Mantle Cell Lymphoma in Latin America: A multinational cohort analysis2025