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December 8, 2025BloodOpen Access

Integrative omics analysis of TP53 in multiple myeloma patients

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Authors

CRCristina De RamónIMIrena MisieweiczMGMaría García‐Álvarez

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Overview

Integrative analysis reveals TP53 mutations impact disease outcome in multiple myeloma patients, indicating new prognostic markers.

Key Points

  • This research aims to explore the impact of TP53 mutations on disease outcomes in multiple myeloma patients.
  • Analyzed bone marrow samples from 150 newly diagnosed multiple myeloma patients.
  • Employed NGS to sequence the TP53 gene and targeted RNA sequencing for gene expression analysis.
  • Quantified microRNA expression and analyzed p53 protein levels using advanced technology.
  • Conducted integrative analysis using Multi-Omics Factor Analysis (MOFA2) in R.
  • Identified TP53 mutations associated with worse progression-free survival and overall survival.
  • Showed 10 single nucleotide variants in TP53 coding DNA sequence in patients impacting progression-free survival.
  • High levels of p53-related microRNAs were associated with lower protein levels and varied impact on survival.

Cite This Study

Ramón et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db77https://doi.org/10.1182/blood-2025-2162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P16 | INTEGRATED p53 ISOFORM EXPRESSION DEFINES NOVEL PROGNOSTIC SUBGROUPS IN MULTIPLE MYELOMA2026
  2. 2Multi-omic and functional screening reveal targetable vulnerabilities in TP53 mutated multiple myeloma2024 · 1 citations
  3. 3Expression patterns of eighteen genes involved in crucial cellular processes in the TP53 pathway in Multiple Myeloma2024
  4. 4Integrating p53-associated genes and infiltrating immune cell characterization as a prognostic biomarker in multiple myeloma2024 · 3 citations
  5. 5Characteristics and prognostic implications of <i>TP53</i> mutations in Chinese patients with myelodysplastic syndromes2025 · 3 citations