What question did this study set out to answer?

To determine the safety and effectiveness of whole brain radiotherapy in primary CNS lymphoma treatment.

December 8, 2025BloodOpen Access

The whole brain radiotherapy is a safe and effective backbone in primary central nervous system lymphoma: A 23-year real-world experience

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Observational analysis reveals whole brain radiotherapy impacts progression-free survival and cognitive impairment in primary CNS lymphoma patients.

To determine the safety and effectiveness of whole brain radiotherapy in primary CNS lymphoma treatment.
Identified patients with biopsy-proven primary CNS lymphoma receiving cranial irradiation from 2000-2022.
Recorded treatment timelines, disease status, and MMSE evaluations for cognitive assessment.
Conducted survival analyses including overall survival and progression-free survival.
72.58% of patients achieved complete remission after whole brain radiotherapy.
Overall survival was significantly better with consolidation WBRT after systemic therapy.
Cognitive impairment was not significantly observed post-WBRT, particularly in older patients.

Chen et al. (2025) studied this question.

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Observational analysis reveals whole brain radiotherapy impacts progression-free survival and cognitive impairment in primary CNS lymphoma patients.