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December 8, 2025BloodOpen Access

Optimizing outcomes and accessibility of matched sibling donor transplantation for severe hemoglobinopathies in low-resource settings

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Authors

RARajat Agarwal

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Overview

Retrospective analysis shows high survival in matched sibling transplant for thalassemia and sickle cell disease, indicating effective low-cost methods are viable.

Key Points

  • This research aims to optimize outcomes and accessibility of matched sibling donor transplantation for severe hemoglobinopathies in low-resource settings.
  • Retrospective analysis of 113 patients
  • Matched sibling donor hematopoietic stem cell transplantation
  • Administration of fludarabine, dexamethasone, busulfan, cyclophosphamide
  • GVHD prophylaxis using cyclosporine and methotrexate
  • Overall survival at 95.6%
  • Thalassemia-free survival at 93.9%
  • GVHD-free survival at 93.1%
  • Graft failure in 2 patients (1.7%)
  • Transplant-related mortality at 4.4%

Cite This Study

Rajat Agarwal (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dba6https://doi.org/10.1182/blood-2025-5987
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