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December 8, 2025BloodOpen Access

Dynamic changes in cytogenetic abnormalities during treatment predict long-term outcomes in multiple myeloma

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Authors

YLYuntong Liu

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Overview

Retrospective analysis shows dynamic cytogenetic changes influence progression-free survival in multiple myeloma, suggesting personalized therapeutic strategies.

Key Points

  • This research aims to evaluate how changes in cytogenetic abnormalities during treatment affect patient outcomes in multiple myeloma.
  • Retrospective analysis of 1,425 newly diagnosed multiple myeloma patients
  • Conducted serial assessments using fluorescence in situ hybridization
  • Evaluated the relationship between cytogenetic changes and patient prognoses
  • High-risk cytogenetic abnormalities lost prognostic significance over time
  • 62.3% of initially high-risk patients showed cytogenetic regression during therapy
  • Patients transitioning from high- to standard-risk profiles had significantly longer progression-free survival

Cite This Study

Yuntong Liu (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dbf9https://doi.org/10.1182/blood-2025-7542
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