What question did this study set out to answer?

To investigate the effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in patients receiving allogeneic hematopoietic transplantation.

December 8, 2025Blood

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

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Authors

JTJose TinajeroCity Of Hope National Medical Center SOSalman OtoukeshCity of Hope SPSunmin ParkCity of Hope

Discussion

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Implication

Retrospective analysis highlights belumosudil's influence on tacrolimus and sirolimus levels in patients, indicating the need for therapeutic drug monitoring.

Key Points

To investigate the effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in patients receiving allogeneic hematopoietic transplantation.
Retrospective review of medical records for 68 patients receiving belumosudil and on either tacrolimus or sirolimus.
Analysis included only patients with IS/S levels available within 35 days of initiating belumosudil.
Measured concentrations and adjusted dosing based on therapeutic drug monitoring (TDM).
Belumosudil increased tacrolimus levels by 25.8% and sirolimus levels by 25%.
20% of patients had supratherapeutic tacrolimus levels and 30.4% had supratherapeutic sirolimus levels.
Severe toxicities were noted in only 13.2% of patients, predominantly with tacrolimus.

Cite This Study

Tinajero et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc11 https://doi.org/10.1182/blood-2025-7612

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Implication

Retrospective analysis highlights belumosudil's influence on tacrolimus and sirolimus levels in patients, indicating the need for therapeutic drug monitoring.

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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