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December 8, 2025BloodOpen Access

Locational patterns and ecological catalysts of cutaneous T-cell lymphoma: Insights from a Louisiana medical center (2019–2024)

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Authors

FKFaradia KernizanCBCarole Bitar

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Overview

Analysis shows significant clustering of cutaneous T-cell lymphoma cases near contaminated sites, indicating possible environmental toxin exposure and racial disparities in diagnosis.

Key Points

  • To investigate whether cutaneous T-cell lymphoma cases aggregate near superfund and toxic release inventory sites in Louisiana.
  • Data collected from electronic medical records (Epic) covering 2019-2024.
  • Identified 378 individuals with confirmed cutaneous T-cell lymphoma (CTCL) diagnoses using ICD codes.
  • Mapped geographic distribution of CTCL cases and proximity to superfund and TRI sites using ArcGIS.
  • Conducted Pearson correlation analysis to assess relationship between CTCL prevalence and distance to contaminated sites.
  • Significant geographic clustering of CTCL cases in specific Louisiana zip codes.
  • Pearson correlation analysis showed a negative correlation between CTCL prevalence and distance to superfund/TRI sites (r = -0.7644, p = 0.038).
  • Demographic analysis revealed racial disparities in CTCL subtypes and diagnosis: higher rates of Mycosis Fungoides in White patients, while Black patients had higher non-lymphoma skin disorder rates.

Cite This Study

Kernizan et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc41https://doi.org/10.1182/blood-2025-8018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1O10 A national retrospective cohort study of the incidence and trends of 3061 cases of cutaneous T-cell lymphoma in England between 2013 and 20202024
  2. 2Role of race in severity and survival of those with cutaneous T-cell lymphoma2025
  3. 3Categorization of Reasons for Hospitalizations in Patients With Cutaneous T‐Cell Lymphoma2026
  4. 4Emerging Epidemiological Trends in Primary Cutaneous Lymphomas: A Population-Based Analysis2025 · 2 citations
  5. 5Pathology of Cutaneous T Cell Lymphoma: A Narrative Review2026 · 2 citations