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December 8, 2025Blood

Disease presentation and immunophenotype characteristics in 257 patients with blastic plasmacytoid dendritic cell neoplasm: A pethema/PALG study

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Authors

IVIrene Navarro VicenteASAmparo SempereJSJoaquín Sánchez‐García

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Overview

Multinational retrospective study reveals immunophenotype and morphology features of BPDCN and lymphadenopathy prevalence.

Key Points

  • This research aims to characterize the disease presentation and immunophenotype of BPDCN.
  • Multinational retrospective study conducted by PALG and PETHEMA groups.
  • Data on clinical presentation, morphology, and immunophenotype gathered from 257 BPDCN patients.
  • Immunohistochemistry and flow cytometry analyses performed to assess marker expression.
  • 257 patients included, with skin involvement in 81% and lymphadenopathy in 49%.
  • Immunophenotype characterized by positive expression of CD4, CD56, and CD123 in most samples.
  • Flow cytometry detected BPDCN cells in 95% of assessed bone marrow cases.

Cite This Study

Vicente et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc45https://doi.org/10.1182/blood-2025-218
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