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December 8, 2025Blood

Improved survival after post-transplant relapse of adult t-cell leukemia-lymphoma and trends of salvage therapy

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Authors

AIAyumu ItoTETetsuya EtoMFMachiko Fujioka

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Overview

Analysis reveals improved survival trends after post-transplant relapse for adult T-cell leukemia-lymphoma, suggesting potential benefits from novel interventions.

Key Points

  • To determine survival trends after post-transplant relapse in adult T-cell leukemia-lymphoma patients.
  • Included 1146 patients who underwent allo-HSCT and experienced post-transplant R/R ATL.
  • Analyzed overall survival using Cox proportional hazards regression models by time period.
  • Collected clinical data from the Transplant Registry Unified Management Program.
  • Significant increase in OS rates in the late period for Refractory group (17.1%).
  • Increased use of salvage therapy agents mogamulizumab and lenalidomide in the late period.
  • Proportion of patients older than 60 and better performance status increased over time.

Cite This Study

Ito et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc8fhttps://doi.org/10.1182/blood-2025-562
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improvements over time in survival after post‐transplant relapse of adult T‐cell leukaemia/lymphoma and trends of salvage therapy in a real‐world experience2026 · 1 citations
  2. 2Three decades of allogeneic transplantation showing improved survival, persistent relapse and post‑relapse outcomes of donor lymphocyte infusion versus second transplant2025
  3. 3Treatment Strategies of Acute Myeloid Leukemia Relapses after Allogeneic Stem Cell Transplantation: Evidence from the GITMO Nationwide Italian Registry2025 · 1 citations
  4. 4Results of treating relapsed and refractory acute myeloid leukemia at a reference center in Latin America: the importance of outpatient hematopoietic stem cell transplantation2024 · 1 citations
  5. 5Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience2025