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December 8, 2025BloodOpen Access

ENO1 promotes Acute Myeloid Leukemia progression through SCD1-mediated lipid metabolism reprogramming

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Authors

YWYijun WuSHShaoyan HuXLXin Liu

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Overview

High ENO1 expression correlates with poor AML outcomes, suggesting SCD1 inhibition may enhance daunorubicin effectiveness.

Key Points

  • This study aims to explore how ENO1 influences tumor progression and lipid metabolism in acute myeloid leukemia.
  • Investigated ENO1 expression in 142 AML patients to correlate with prognosis.
  • Conducted RNA sequencing on ENO1-knockdown cells to analyze molecular pathways.
  • Performed metabolomic analysis to assess lipid metabolism changes.
  • Utilized KEGG pathway enrichment to identify significant metabolic associations.
  • Patients with high ENO1 had lower event-free survival rates compared to those with low expression.
  • ENO1 knockdown cells showed reduced growth and heightened sensitivity to ferroptosis.
  • Found that ENO1 regulates SCD1, affecting fatty acid metabolism and membrane lipid homeostasis.
  • Combining SCD1 inhibition with daunorubicin effectively reduced resistance observed in high ENO1 expressing AML cells.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcc0https://doi.org/10.1182/blood-2025-1471
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