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December 8, 2025BloodOpen Access

EZH2 oncogenic mutation disrupts germinal center B cell dynamics and promotes early lymphomagenic behaviors

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Authors

KCKibaek ChoeAMAri MelnickWBWendy Béguelin

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Overview

Mechanistic insights unveil how EZH2 mutations disturb B cell dynamics in follicular lymphoma, suggesting altered spatial organization.

Key Points

  • This research aims to elucidate how EZH2 mutations reprogram B cell dynamics and immune interactions in germinal centers, influencing lymphomagenesis.
  • Performed intravital two-photon microscopy to visualize B cell dynamics in vivo.
  • Conducted high-dimensional single-cell behavioral and transcriptomic analyses to characterize B cell behavior.
  • Generated genetically modified mice with fluorescent labels for tracking B cells and immune interactions.
  • Mutant EZH2 B cells showed increased motility and morphological deformability in the light zone.
  • Defective transitions to the dark zone were observed, leading to reduced interzonal migration.
  • Enhanced reliance on follicular dendritic cell signaling indicated altered B cell behavior.

Cite This Study

Choe et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcc4https://doi.org/10.1182/blood-2025-1479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract IA008: Epigenetic regulation of the lymphoma microenvironment: from single-cell behavioral reprogramming to systems-level niche corruption2026
  2. 2Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma2024 · 1 citations
  3. 3Multiple reciprocal interactions within B-cell receptor and AKT signaling pathways regulate response to EZH2 inhibition in germinal center-derived diffuse large B-cell lymphoma2025
  4. 4Developmental stage and cellular context determine oncogenic and molecular outcomes of 2025 · 1 citations
  5. 5Abstract PR005: Mutant FOXO1 licenses MYC transformation of human germinal center B cells into dark-zone MYC-BCL2 high-grade B cell lymphomas2026