Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity

View Full Paper
Ask AI
Bookmark
Share

Authors

XHXin HeGMGuido Marcucci

Discussion

Loading...

Member takes

Overview

Pharmacological inhibition of CTPS1 enhances macrophage M1 polarization and anti-leukemia immunity, indicating therapeutic potential.

Key Points

  • To explore the effects of CTPS1 targeting on macrophage activity and anti-leukemia immunity.
  • Administered CTPS1 inhibitor STP-B in a syngeneic leukemia mouse model for 3 weeks.
  • Used flow cytometry to assess macrophage populations and polarization.
  • Conducted transcriptomic profiling and phagocytosis assays with bone marrow-derived macrophages.
  • STP-B treatment increased macrophage M1 polarization and reduced leukemia burden.
  • Macrophage depletion abolished survival advantages seen with STP-B treatment.
  • Transcriptomic analysis revealed upregulation of M1-related genes in treated macrophages.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dce0https://doi.org/10.1182/blood-2025-1490
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2572: Pharmacological targeting of CTPS1 elicits macrophage-mediated anti-leukemia immunity2026
  2. 2Selective pharmacologic targeting of CTPS1 shows single-agent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma2024 · 4 citations
  3. 3CTPS1 modulates mitophagy to propel diffuse large B-cell lymphoma via reshaping CEPT1-mediated phospholipid metabolism2026
  4. 4MDB-101. TARGETING CTPS1 AND NUCLEOTIDE BIOSYNTHESIS PATHWAYS AS A NOVEL THERAPEUTIC APPROACH IN MYC-AMPLIFIED MEDULLOBLASTOMA2024
  5. 5Cytidine triphosphate synthase 1-mediated metabolic reprogramming promotes proliferation and drug resistance in multiple myeloma2024 · 7 citations