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December 8, 2025BloodOpen Access

Proteomic analysis identifying biomarkers in the progression from essential thrombocythemia to post-essential thrombocythemia myelofibrosis: A retrospective cohort study

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TSTing Sun

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Overview

Cohort study identifies biomarkers through proteomic analysis in patients with essential thrombocythemia and post-ET myelofibrosis, indicating chronic inflammation and immune response involvement.

Key Points

  • This study aims to identify biomarkers associated with the progression from essential thrombocythemia to post-essential thrombocythemia myelofibrosis.
  • Conducted a cohort study of patients diagnosed with ET and post-ET MF.
  • Utilized logistic regression to identify clinical variables and machine learning for proteomic profiling.
  • Performed gene ontology and KEGG enrichment analyses to explore proteins' biological functions.
  • Identified key biomarkers including hemoglobin and lactate dehydrogenase as predictors of disease progression.
  • Machine learning revealed nine differentially expressed proteins linked to fibrotic transformation.
  • Enrichment analyses highlighted pathways related to extracellular matrix organization and immune response.

Cite This Study

Ting Sun (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd5dhttps://doi.org/10.1182/blood-2025-1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis2024 · 1 citations
  2. 2A Proteomics-Driven Machine Learning Tool for Distinguishing ET from pre-PMF2025
  3. 3Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis2026
  4. 4Predictors of fibrotic progression in myeloproliferative neoplasms: A real-world retrospective cohort study.2026
  5. 5Dysregulation of the immune microenvironment in essential thrombocythemia: the interplay of core genes and inflammation-related signaling pathways2026 · 1 citations