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December 8, 2025BloodOpen Access

Risk of secondary chronic myeloid leukemia in cancer survivors: A nationwide population-based study in Taiwan

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Authors

CLChia-Jen Liu

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Overview

Retrospective cohort study identifies diabetes and male sex as risk factors for secondary CML in cancer survivors, suggesting a need for monitoring.

Key Points

  • This study aims to investigate the risk of secondary chronic myeloid leukemia (CML) in cancer survivors and identify clinical predictors.
  • Conducted a retrospective cohort study using Taiwan's National Health Insurance Research Database and Cancer Registry data from 2000 to 2021.
  • Identified and followed patients with a primary malignancy for secondary CML development.
  • Excluded patients under 18, those missing demographic data, and patients with hematologic malignancies.
  • 191 patients developed secondary CML, with an incidence of 2.55 per 100,000 person-years.
  • Highest incidence rates were in patients with central nervous system and gastrointestinal cancers.
  • Multivariate analysis identified male sex, diabetes mellitus, and heart failure as independent risk factors.

Cite This Study

Chia-Jen Liu (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd66https://doi.org/10.1182/blood-2025-1994
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  4. 4Beyond survival in chronic myeloid leukemia: A systematic review of secondary malignancies in the era of tyrosine kinase inhibitors2025
  5. 5Second primary malignancies in Asian chronic lymphocytic leukaemia patients: A Taiwan Cancer Registry Study2026