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December 8, 2025BloodOpen Access

The central role of liver stifness measurement in adults with transfusion dependent thalassemia (TDT) beyond what could be informed by liver iron concentration

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Authors

RLRoberto LisiAPA PasanisiLFLucia De Franceschi

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Overview

Retrospective cohort study shows liver stiffness predicts liver fibrosis risk in TDT patients, suggesting key implications for treatment.

Key Points

  • Investigate the role of liver stiffness measurement in assessing liver disease risk among TDT patients.
  • Conducted a retrospective cohort study of 223 TDT patients in Italy.
  • Patients underwent liver stiffness measurement using transient elastography (Fibroscan).
  • Excluded patients with HIV or hepatocellular carcinoma.
  • Performed bivariate and multivariate analyses to assess associations.
  • 22% of patients had liver stiffness values indicating advanced fibrosis (≥8 kPa).
  • Significant associations found between liver stiffness and age, gender, ferritin, and HCV status.
  • Subgroup analyses highlighted liver stiffness as a critical indicator even when liver iron concentration is low.

Cite This Study

Lisi et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddddhttps://doi.org/10.1182/blood-2025-2918
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Emerging Role of Liver Stiffness Measurement in Transfusion Dependent Thalassemia2026
  2. 2Liver Stiffness and Fibrosis Used as Early Diagnosis of Patients with Chronic Liver Disease in A Retrospective Cross-Sectional Study2024 · 1 citations
  3. 3Liver steatosis in patients with transfusion‐dependent thalassaemia2024 · 2 citations
  4. 4Obesity, liver steatosis and metabolic syndrome: The hidden enemies in transfusion‐dependent thalassaemia2024 · 5 citations
  5. 5The relationship between liver stiffness by two-dimensional shear wave elastography and iron overload status in transfusion-dependent patients2024