What question did this study set out to answer?

To elucidate how hemin affects the metabolism of sickle cell erythroblasts and regulates redox homeostasis.

December 8, 2025BloodOpen Access

Metabolomic and epigenetic signatures of hemin-induced stress in sickle cell erythroblasts

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Authors

BPBetty S. PaceAugusta University XZXingguo ZhuAugusta University

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Implication

This investigation reveals hemin-induced ferroptosis in sickle cell erythroblasts, suggesting the role of epigenetic and redox homeostasis alterations.

Key Points

To elucidate how hemin affects the metabolism of sickle cell erythroblasts and regulates redox homeostasis.
Isolated CD34⁺ hematopoietic stem cells from SCD patients
Cultured cells under hypoxic conditions to assess impact of hemin
Performed metabolomic profiling, RNA sequencing, and ATAC-seq analyses
Hemin disrupts redox homeostasis and induces ferroptosis in SCD erythroblasts under hypoxia
Transcriptomic analysis shows altered expression of key genes involved in glutathione and nucleotide metabolism
Hemin promotes histone hypermethylation and disrupts TCA cycle activity

Cite This Study

Pace et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236dddf https://doi.org/10.1182/blood-2025-2924

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Implication

This investigation reveals hemin-induced ferroptosis in sickle cell erythroblasts, suggesting the role of epigenetic and redox homeostasis alterations.

Metabolomic and epigenetic signatures of hemin-induced stress in sickle cell erythroblasts

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolomic and epigenetic signatures of hemin-induced stress in sickle cell erythroblasts

Discussion

Member takes

Implication

Key Points

Cite This Study

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