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December 8, 2025BloodOpen Access

Cell-free DNA (cfDNA) and plasma proteomics reveal inflammatory heterogeneity in vaso-occlusive crises in sickle cell disease (SCD).

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Authors

AMArden McAllister

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Overview

Proteomic analysis identifies molecular pathways during vaso-occlusive crises in sickle cell disease, suggesting potential biomarkers for inflammation-driven episodes.

Key Points

  • To identify inflammatory markers and molecular pathways in vaso-occlusive crises in sickle cell disease using plasma proteomics and cfDNA.
  • Enrolled 46 individuals with sickle cell disease experiencing vaso-occlusive crises.
  • Collected and analyzed matched plasma samples using high-throughput proteomic profiling.
  • Conducted principal component analysis and correlation analysis between cfDNA and protein levels.
  • Identified 38 differentially expressed proteins during vaso-occlusive crises compared to baseline.
  • Elevation of immune-related cytokines and components of the ubiquitin-proteasome system during crises.
  • cfDNA levels correlated with a broad inflammatory proteomic signature and were distinct among subtypes.

Cite This Study

Arden McAllister (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236dde7https://doi.org/10.1182/blood-2025-2930
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigation of predictive markers of disease complications in children with sickle cell disease: Preliminary findings from a multicenter prospective inception cohort study2025
  2. 2Metabolomic and Proteomic Profiling of Vaso-Occlusive Crises in Sickle Cell Disease: Current Evidence and Future Perspectives2026
  3. 3C95-04 Multiomic Analysis of Coordinated Airway and Systemic Inflammatory Responses in Children With Sickle Cell Disease2026
  4. 4Gene expression profiling identifies potential biomarkers for vaso-occlusive episodes in sickle cell disease2026
  5. 5Changes in circular RNA expression in acute chest syndrome and vaso-occlusive crisis in sickle cell disease: analysis of a public RNA-seq cohort2026