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December 8, 2025BloodOpen Access

Investigation of predictive markers of disease complications in children with sickle cell disease: Preliminary findings from a multicenter prospective inception cohort study

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Authors

MAMaua AlleyneAEAnna EidenbergerHWHope P. Wilson

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Overview

Multicenter cohort study identifies inflammation and biomarkers linked to acute chest syndrome and vaso-occlusive crisis in pediatric sickle cell disease.

Key Points

  • The aim is to identify plasma markers predictive of complications in children with sickle cell disease.
  • Multicenter prospective inception cohort study
  • Included children under 21 years with sickle cell disease
  • Plasma markers were assessed during acute presentations and follow-ups
  • Data analyzed via descriptive statistics and logistic regression
  • Higher plasma levels of CXCL10, VEGFA, and VCAM-1 found in acute chest syndrome vs vaso-occlusive crisis
  • CXCL10 independently associated with acute chest syndrome development (OR=1.13)
  • Majority of children had single hospital admission; some had recurrent admissions with higher biomarker levels

Cite This Study

Alleyne et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de09https://doi.org/10.1182/blood-2025-4746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Complement dysregulation during vaso-occlusive episodes can predict development of acute chest syndrome in pediatric patients with sickle cell disease2025
  2. 2Predictors of Acute Chest Syndrome Following Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease2026 · 1 citations
  3. 3Cell-free DNA (cfDNA) and plasma proteomics reveal inflammatory heterogeneity in vaso-occlusive crises in sickle cell disease (SCD).2025
  4. 4C95-04 Multiomic Analysis of Coordinated Airway and Systemic Inflammatory Responses in Children With Sickle Cell Disease2026
  5. 5Circulating biomarkers associated with pediatric sickle cell disease2024 · 9 citations