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December 8, 2025Blood

Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial

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Authors

GAGladstone AireweleNBNitya BakshiDBDavid C. Brousseau

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Overview

Randomized controlled trial reveals high prevalence of acute chest syndrome in sickle cell disease, indicating management variability in emergency departments.

Key Points

  • Assess prevalence of acute chest syndrome in children and young adults with sickle cell disease during vaso-occlusive episodes and evaluate management variations.
  • Conducted a multicenter, double-blinded, randomized, placebo-controlled phase-3 trial
  • Analyzed data from patients aged 3-21 hospitalized with vaso-occlusive episodes
  • Defined acute chest syndrome via clinical diagnosis and chest radiographs
  • 20% of patients developed acute chest syndrome during hospitalization
  • Significant clinical variations noted, including length of stay and oxygen utilization
  • Emergency department presentations often showed normal respiratory examinations despite acute chest syndrome

Cite This Study

Airewele et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d98dhttps://doi.org/10.1182/blood-2025-2946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  2. 2C65-12 Clinical and Laboratory Findings in Adults With Sickle Cell Disease Which Increase Risk for Severe Acute Chest Syndrome2026
  3. 3Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises2024 · 3 citations
  4. 4B52-42 Not Just Another Crisis Severe Atypical Acute Chest Syndrome2026
  5. 5Predictors of Acute Chest Syndrome Following Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease2026 · 1 citations