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December 8, 2025BloodOpen Access

Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome

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Authors

JLJason LoftersCCCassandra ChuaBMBharath Miriyam

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Overview

Findings reveal that anemia and other risk factors predict severe acute chest syndrome in adults with sickle cell disease, indicating the need for intensive care.

Key Points

  • To determine predictive risk factors for severe acute chest syndrome (ACS) in adults with sickle cell disease (SCD).
  • Analyzed adult SCD patients hospitalized from 2021 to 2022.
  • Used electronic medical records and ICD-10 codes for case confirmation.
  • Data on demographics, vital signs, and treatments were collected.
  • SCOGS severity scale was applied to classify ACS cases by severity.
  • Statistical analyses included ANOVA and descriptive statistics.
  • Of 112 hospitalizations, 109 cases met ACS criteria and were graded with SCOGS.
  • Severe ACS characterized by low oxygen saturation (92.3%) and higher total bilirubin.
  • Anemia significantly associated with severe ACS (p=0.02).
  • Four deaths occurred, one unrelated to ACS.
  • Prior ACS episodes were noted in 86.6% of cases.

Cite This Study

Lofters et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e49ahttps://doi.org/10.1182/blood-2025-1175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C65-12 Clinical and Laboratory Findings in Adults With Sickle Cell Disease Which Increase Risk for Severe Acute Chest Syndrome2026
  2. 2Application and challenges of the sickle cell outcome grading system (SCOGS) for classifying acute chest syndrome severity2025
  3. 3B52-42 Not Just Another Crisis Severe Atypical Acute Chest Syndrome2026
  4. 4Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations
  5. 5Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises2024 · 3 citations