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December 8, 2025BloodOpen Access

Application and challenges of the sickle cell outcome grading system (SCOGS) for classifying acute chest syndrome severity

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Authors

JWJoseph WardellJLJ. Russell LipfordMWMatthew D. Wogksch

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Overview

Application of the SCOGS improves oxygen therapy classification in acute chest syndrome, indicating challenges for severity assessment.

Key Points

  • This research evaluates the application of the Sickle Cell Outcome Grading System (SCOGS) in classifying acute chest syndrome (ACS) severity in sickle cell disease.
  • Applied SCOGS to pediatric and adult cohorts with sickle cell disease.
  • Utilized clinical and demographic variables for ACS severity quantification.
  • Conducted analyses using R and SAS across two cohorts.
  • In SCCRIP, 73.2% of ACS episodes were classified as Grade 1 with significant missing data.
  • The BMC cohort recorded higher severity grades, with cases reaching Grade 4 and 5.
  • Missing data for oxygen therapy hindered scoring in SCCRIP, impacting severity classification.

Cite This Study

Wardell et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9aahttps://doi.org/10.1182/blood-2025-2969
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  2. 2Assessing replicability in chronic kidney disease severity scoring classifications using the sickle cell outcome grading system2025
  3. 3C65-12 Clinical and Laboratory Findings in Adults With Sickle Cell Disease Which Increase Risk for Severe Acute Chest Syndrome2026
  4. 4Machine learning replicates and extends clinician-informed disease severity grading classification for acute pain and CKD in sickle cell disease2025
  5. 5Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations