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December 8, 2025BloodOpen Access

Pilot study on thrombosis risk factors in sickle cell anemia

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Authors

NDNicoy DownieMFMaura A. FaganSAS Alkhalili

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Overview

Pilot study found elevated hemoglobin and lack of hydroxyurea predict thrombosis in sickle cell anemia patients, highlighting the need for further validation.

Key Points

  • This study aims to identify the risk factors for thrombosis in patients with sickle cell anemia and develop a risk stratification tool.
  • Conducted a retrospective, matched case-control study from 2013 to 2023.
  • Included 49 adults with sickle cell anemia: 26 with thrombosis and 23 matched controls.
  • Collected laboratory values at steady state and assessed several biomarkers and clinical variables.
  • Used logistic regression and ROC curve analysis to evaluate model performance.
  • Hemoglobin levels significantly higher in thrombosis cases compared to controls (8.6 vs. 7.7 g/dL, p = 0.041).
  • Hydroxyurea use was significantly lower in thrombosis cases (p = 0.012).
  • Hospitalization frequency was higher in thrombosis cases but did not reach statistical significance (2.5 vs. 1.0 per year, p = 0.067).
  • Logistic regression revealed hemoglobin and hydroxyurea use as independent predictors of thrombosis (AUC 0.83).

Cite This Study

Downie et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4b5https://doi.org/10.1182/blood-2025-1191
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  5. 5The Natural Coagulation Inhibitors, Inflammation, and Thrombotic Risk in Sickle Cell Patients in Cameroon: An Analytical Cross‐Sectional Study2026