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December 8, 2025Blood

Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)

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Authors

AIAjay IyerUniversity College Dublin

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Implication

Retrospective analysis shows higher odds of VTE hospitalizations in sickle cell disease adults, indicating a need for preventive strategies.

Key Points

  • This research aims to assess the frequency and characteristics of venous thromboembolism-related hospitalizations among adults with sickle cell disease in the U.S.
  • Conducted a retrospective cross-sectional analysis using the National Inpatient Sample for 2016-2020.
  • Identified hospitalizations with primary VTE diagnosis using ICD-10-CM codes and stratified by secondary SCD diagnosis.
  • Compared patient demographics, comorbidities, and mortality rates between SCD and non-SCD VTE admissions.
  • 0.5% of VTE hospitalizations occurred in patients with sickle cell disease.
  • SCD patients with VTE were younger, with a mean age of 41.4 years compared to 63.1 for non-SCD patients.
  • Higher adjusted odds (1.95) of VTE hospitalization in SCD patients despite similar in-hospital mortality rates compared to non-SCD.

Cite This Study

Ajay Iyer (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e13ahttps://doi.org/10.1182/blood-2025-4751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study2025
  2. 2Increased incidence of VTE in sickle cell disease patients: risk factors, recurrence and impact on mortality2017 · 132 citations
  3. 3Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis2026
  4. 4Hospital acquired venous thromboembolism in children with sickle cell disease2024 · 2 citations
  5. 5Prevention and management of indwelling catheter‐related thrombosis in sickle cell disease and thalassaemia: A British Society for Haematology Good Practice Paper2024 · 7 citations