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December 8, 2025BloodOpen Access

Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study

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Authors

ASAshish Kumar SharmaSanjay Gandhi Post Graduate Institute of Medical SciencesATAngad TiwariMaharani Laxmi Bai Medical College

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Overview

Nationwide inpatient sample study finds significant racial disparities in VTE management for sickle cell disease patients.

Key Points

  • Evaluate the disparities in VTE diagnosis and management among patients with sickle cell disease.
  • Conducted a retrospective study using the National Inpatient Sample from 2019 to 2021
  • Identified hospitalizations with sickle cell disease and VTE diagnoses
  • Explored patient demographics and VTE-related treatments
  • Utilized multivariable logistic regression to identify predictors of treatment and mortality
  • 88.1% of SCD and VTE hospitalizations were African American patients
  • Reduced anticoagulant medication chances (aOR 0.72) and higher IVC filter usage (aOR 1.34) in African Americans
  • In-hospital mortality was higher for patients not on anticoagulation (4.9% vs 1.8%)
  • Medicaid recipients were less likely to receive thrombolysis (aOR 0.68)

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9bdhttps://doi.org/10.1182/blood-2025-2974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)2025
  2. 2Racial and socioeconomic disparities in transfusion utilization among hospitalized sickle cell disease patients: An analysis of the 2022 national inpatient sample2025
  3. 3Increased incidence of <scp>VTE</scp> in sickle cell disease patients: risk factors, recurrence and impact on mortality2017 · 132 citations
  4. 4Prevention and management of indwelling catheter‐related thrombosis in sickle cell disease and thalassaemia: A British Society for Haematology Good Practice Paper2024 · 7 citations
  5. 5A Systematic Review with Meta-Analysis on Racial and Ethnic Disparities in Acute Venous Thromboembolism Diagnosis and Management.2026