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December 8, 2025BloodOpen Access

Racial and socioeconomic disparities in transfusion utilization among hospitalized sickle cell disease patients: An analysis of the 2022 national inpatient sample

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Authors

IPIn-Ae ParkYCYoon‐Hee Choi

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Overview

Analysis reveals racial disparities in transfusion therapy and mortality rates for hospitalized sickle cell disease patients, suggesting improvement needs.

Key Points

  • The aim is to evaluate disparities in transfusion rates, mortality, and ICU-level interventions among hospitalized sickle cell disease patients.
  • Analyzed 2022 National Inpatient Sample data using ICD-10-CM and ICD-10-PCS codes for transfusions and ICU interventions.
  • Utilized survey-weighted logistic regression to assess predictors of transfusion and mortality rates across hospital types and regions.
  • Defined inpatient mortality based on discharge status in the NIS data.
  • Identified 120,275 SCD-related hospitalizations, with Black patients having an AOR of 2.40 for transfusions compared to White patients.
  • Transfusion rates were highest in rural hospitals (30.3%) and lowest in urban teaching hospitals (20.9%).
  • Inpatient mortality was highest in the Midwest region (3.4/1,000 discharges), indicating significant regional disparities.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db00https://doi.org/10.1182/blood-2025-4724
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A global survey of blood transfusion practices for patients with sickle cell disease2026
  2. 2Disparities in venous thromboembolism management in patients with sickle cell disease: A nationwide inpatient sample study2025
  3. 3Treatment disparities in sickle cell disease among patients with asymptomatic HIV2025
  4. 4Trends, Predictors, and Outcomes of Critically Ill Patients With Sickle Cell Disease in the United States2025 · 1 citations
  5. 5Geographic and temporal trends in sickle cell disease hospitalizations in New York State2025