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December 8, 2025BloodOpen Access

Treatment disparities in sickle cell disease among patients with asymptomatic HIV

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Authors

AAAbdullah AhmadMAMeher Ayyazuddin

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Overview

Retrospective analysis reveals underuse of transfusions in sickle cell disease patients with HIV, highlighting socioeconomic disparities.

Key Points

  • To investigate treatment disparities in hospitalized patients with sickle cell disease and asymptomatic HIV.
  • Retrospective cross-sectional analysis using the National Inpatient Sample (2016 - 2020)
  • Identified asymptomatic HIV cases using ICD-10 Z21
  • Outcomes included transfusion types and other interventions; analyses used chi-square tests and logistic regression.
  • HIV-positive patients experienced higher comorbidity rates, yet received fewer transfusions and exchange transfusions.
  • Dialysis usage was three times higher among HIV-positive patients with severe comorbidities.
  • In-hospital mortality rates were similar, despite higher illness severity among the HIV group.

Cite This Study

Ahmad et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfa4https://doi.org/10.1182/blood-2025-6216
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial and socioeconomic disparities in transfusion utilization among hospitalized sickle cell disease patients: An analysis of the 2022 national inpatient sample2025
  2. 2HIV-1–Infected SCD patients exhibit milder sickle cell disease and suppressed antiviral innate immune responses2025
  3. 3Hematologic and Immunologic Crossroads: HIV in Sickle Cell Disease Patients2025
  4. 4A global survey of blood transfusion practices for patients with sickle cell disease2026
  5. 5A66-04 Inpatient Outcomes and Mortality of Congestive Heart Failure in Sickle Cell Disease: A Retrospective Nationwide Analysis2026