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December 8, 2025Blood

A united-states nationwide analysis of sickle cell genotype-specific differences in inpatient outcomes

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Authors

RKRoy L. Kao

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Overview

Nationwide analysis shows Hb-SC genotype has higher mortality and healthcare utilization in sickle cell disease patients during vaso-occlusive crisis.

Key Points

  • This research aims to compare inpatient outcomes and healthcare utilization across different sickle cell genotypes during vaso-occlusive crisis.
  • Analyzed admissions from the National Inpatient Sample database (2016 - 2019) for sickle cell disease with vaso-occlusive crisis.
  • Stratified subjects by genotype using ICD-10 codes.
  • Applied Pearson's Chi-Squared test and Student's t-tests for statistical analysis of outcomes.
  • Used multivariate logistic regression to adjust for confounders like age and comorbidities.
  • Out of 71,536 admissions, Hb-SS was the most common genotype identified.
  • Patients with Hb-SC had significantly higher mortality rates and hospitalization costs compared to those with Hb-SS.
  • Mechanical ventilation was required more often in patients with Hb-SC.
  • Renal replacement therapy and red blood cell transfusion were less frequent in Hb-SC compared to Hb-SS.

Cite This Study

Roy L. Kao (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dcb3https://doi.org/10.1182/blood-2025-945
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  3. 3Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin <scp>SS</scp> and Hemoglobin <scp>SC</scp> Disease: An Extended Systematic Review2026
  4. 4Hemoglobin S beta thalessemia plus: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  5. 5Risk of vaso-occlusive crisis requiring hospitalization in sickle cell disease patients in Brazil: retrospective cohort study of real-world data2025