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December 8, 2025Blood

Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.

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Authors

AAA.A. AjayiRFRoss M. Fasano

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Overview

Retrospective evaluation shows significant complications in HbSC patients, indicating a need for tailored management strategies.

Key Points

  • Evaluate clinical manifestations, treatment response, and complications in adults with HbSC disease.
  • IRB-approved retrospective study at Georgia Comprehensive Sickle Cell Center
  • Included adults with HbSC confirmed by electrophoresis
  • Variables collected included demographics, comorbidities, and SCD-related complications
  • Statistical analysis utilized t-tests, chi-square, and multivariate regression
  • 303 patients evaluated, with significant complications observed including avascular necrosis and chronic kidney disease
  • Hydroxyurea showed mild impact on hemoglobin levels without significant changes to healthcare utilization
  • High percentage of patients experienced acute chest syndrome and venous thromboembolism during hospitalization
  • Distinct age-related complications noted, with early-onset retinopathy and late-onset sensorineural hearing loss

Cite This Study

Ajayi et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfb7https://doi.org/10.1182/blood-2025-6533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemoglobin S beta thalessemia plus: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  2. 2HbSC disease: Not as benign as you think2026
  3. 3Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  4. 4Improvement of sickle cell disease care mitigates the healthcare utilization induced by increased prevalence: Experience of a tertiary pediatric center2025
  5. 5PO85 | Acute retinal ischemia in hemoglobin SC disease: a case report and review of the literature2025