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December 8, 2025Blood

Hemoglobin S beta thalessemia plus: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.

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Authors

EREldrida RandallRFRoss M. FasanoFRFuad El Rassi

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Overview

Retrospective study examines healthcare utilization and opioid patterns in sickle cell disease patients, suggesting high disease burden.

Key Points

  • This study aimed to assess clinical features and healthcare utilization patterns in patients with HbSβ+.
  • Retrospective analysis at Georgia Comprehensive Sickle Cell Center.
  • Adults (≥18 years) with HbSβ+ from 2015-2025 were included.
  • Data on hemoglobin, fetal hemoglobin percentage, reticulocyte count, and lactate dehydrogenase were collected.
  • Acute healthcare visits, hospitalizations, and opioid utilization patterns were analyzed.
  • 193 patients analyzed with significant comorbidities including chronic kidney disease and avascular necrosis.
  • 30.1% exhibited chronic opioid use; high healthcare utilization linked to chronic pain and psychiatric disorders.
  • Patients with elevated LDH/platelet ratios presented significantly higher odds of complications.
  • Mortality rate was 8.3%, with over two-thirds related to sickle cell disease.

Cite This Study

Randall et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e34chttps://doi.org/10.1182/blood-2025-411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  2. 2A united-states nationwide analysis of sickle cell genotype-specific differences in inpatient outcomes2025
  3. 3Pilot study on thrombosis risk factors in sickle cell anemia2025
  4. 4HbSC disease: Not as benign as you think2026
  5. 5Association of obstructive sleep apnea with readmission and healthcare utilization in adults with sickle cell disease: A propensity-matched analysis of national readmission data2025