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December 8, 2025BloodOpen Access

Social isolation and patient-reported and healthcare utilization in adults with sickle cell disease

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Authors

ACAllen ChengAustralian Regenerative Medicine Institute

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Implication

Cross-sectional study links social isolation to poorer emotional health in sickle cell disease patients, suggesting need for better support.

Key Points

  • To examine the prevalence of social isolation and its association with patient-reported outcomes and healthcare utilization in adults with sickle cell disease.
  • Cross-sectional study of adults with sickle cell disease at MGH
  • Surveyed social isolation, social support effectiveness, quality of life, and psychological symptoms
  • Utilized linear regression for patient-reported outcomes and logistic regression for healthcare utilization outcomes
  • 41.5% reported severe sickle cell disease
  • Higher social isolation linked to lower emotional health and increased anxiety and depression symptoms
  • Social support associated with improved emotional health and lower psychological symptoms

Cite This Study

Allen Cheng (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e213https://doi.org/10.1182/blood-2025-4450
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physical impact and health-related quality of life of SCD in adults: the Real-World Portuguese ASCEND Study2026
  2. 2Developmental interconnections in SCD: a bio-psycho-social model of health from childhood to young adulthood2026
  3. 3Health Related Quality of Life and Psychosocial Profile of Patients with Sickle Cell Disease and Their Caregivers2024
  4. 4Exploring the relationship between health-related stigma and perceived discrimination among adults with sickle cell disease2025
  5. 5A Mixed-Methods Study to Explore Healthcare Utilization Among Children and Adolescents With Sickle Cell Disease During the COVID-19 Pandemic2025