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December 8, 2025Blood

Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis

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Authors

BFBolivia FernandesASAmara SofiaMMMichael Maroules

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Overview

Analysis shows psychiatric comorbidities affect mortality and hospital costs in sickle cell disease, suggesting need for integrated care.

Key Points

  • This research investigates the impact of psychiatric comorbidities on outcomes for sickle cell disease patients during hospitalization.
  • Analyzed 105,938 SCD hospitalizations using the 2020–2022 National Inpatient Sample.
  • Identified psychiatric comorbidities using ICD-10 codes from diagnosis fields.
  • Utilized multivariable models including logistic regression for mortality assessment.
  • 11.4% of SCD patients had major depressive disorder while 10.9% had anxiety.
  • MDD and substance use disorder associated with lower in-hospital mortality rates.
  • Anxiety linked to increased hospital length of stay and costs; substance use disorders reduced costs.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e216https://doi.org/10.1182/blood-2025-4447
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  1. 1Psychiatric Comorbidity in Heart Failure: Associations With Length of Stay, Costs, and Mortality in a National Cohort2026
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  4. 4C65-06 Pulmonary Hypertension in Sickle Cell Disease: A Marker of Advanced Multimorbidity and Mortality2026
  5. 5A66-04 Inpatient Outcomes and Mortality of Congestive Heart Failure in Sickle Cell Disease: A Retrospective Nationwide Analysis2026