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December 8, 2025Blood

Association between comorbid depression and antidepressant adherence with adherence to disease-modifying therapies in patients with sickle cell disease in Texas Medicaid

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Authors

BOBlessing I. OkoyeJBJamie C. Barner

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Overview

Retrospective analysis reveals higher depression rates reduce adherence to disease-modifying therapies in sickle cell disease patients.

Key Points

  • To determine the relationship between comorbid depression, antidepressant adherence, and adherence to disease-modifying therapies in patients with sickle cell disease.
  • Retrospective analysis of Texas Medicaid data from 2016 to 2023
  • Included patients with sickle cell disease having at least 3 medical claims and 1 prescription claim for DMT
  • Adherence estimated using proportion of days covered
  • Logistic regression used for statistical analysis
  • 35.3% of patients with sickle cell disease had depression
  • Significant differences in SCD-related complications and adherence rates identified
  • Adherent patients exhibited better adherence to SCD DMTs, especially those also adherent to antidepressants

Cite This Study

Okoye et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfa0https://doi.org/10.1182/blood-2025-6219
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease2026 · 1 citations
  2. 2Impact of Antidepressant Drug Adherence on Comorbid Medication Use and Resource Utilization2005 · 122 citations
  3. 3Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis2025
  4. 4Association between depression and medication adherence in noncommunicable diseases: a narrative review2025 · 8 citations
  5. 5Impact of adherence to antidepressants on healthcare outcomes and costs among patients with type 2 diabetes and comorbid major depressive disorder2017 · 19 citations