What question did this study set out to answer?

The aim is to explore the association between comorbid depression, antidepressant adherence, and adherence to disease-modifying therapies among Texas Medicaid patients with sickle cell disease.

June 27, 2026Journal of Managed Care & Specialty Pharmacy

Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease

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Authors

BOBlessing I. Okoye JBJamie C. Barner HKHyeun Ah Kang

Discussion

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Overview

Retrospective study finds links between depression, antidepressant use, and therapy adherence in Medicaid patients.

Key Points

The aim is to explore the association between comorbid depression, antidepressant adherence, and adherence to disease-modifying therapies among Texas Medicaid patients with sickle cell disease.
Analyzed Texas Medicaid claims data from 01/2016 to 08/2023.
Included individuals aged 8 to 63 years with at least 3 claims for sickle cell disease and 1 for disease-modifying therapy.
Measured adherence using the proportion of days covered and used multivariable logistic regression for analysis.
33% of patients with sickle cell disease had comorbid depression.
Antidepressant-adherent patients had 16.70 times higher odds of adhering to sickle cell disease DMTs (PDC ≥ 70%) compared to nonadherent patients.
Mean adherence to antidepressants among treated patients was 43.3%, with only 20.5% showing high adherence (PDC ≥ 80%).

Cite This Study

Okoye et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953efe4 https://doi.org/10.18553/jmcp.2026.32.7.832

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June 27, 2026Journal of Managed Care & Specialty Pharmacy

Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease

View Full Paper

Ask AI

Bookmark

Authors

BOBlessing I. Okoye JBJamie C. Barner HKHyeun Ah Kang

Discussion

Member takes

Overview

Retrospective study finds links between depression, antidepressant use, and therapy adherence in Medicaid patients.

Key Points

The aim is to explore the association between comorbid depression, antidepressant adherence, and adherence to disease-modifying therapies among Texas Medicaid patients with sickle cell disease.
Analyzed Texas Medicaid claims data from 01/2016 to 08/2023.
Included individuals aged 8 to 63 years with at least 3 claims for sickle cell disease and 1 for disease-modifying therapy.
Measured adherence using the proportion of days covered and used multivariable logistic regression for analysis.
33% of patients with sickle cell disease had comorbid depression.
Antidepressant-adherent patients had 16.70 times higher odds of adhering to sickle cell disease DMTs (PDC ≥ 70%) compared to nonadherent patients.
Mean adherence to antidepressants among treated patients was 43.3%, with only 20.5% showing high adherence (PDC ≥ 80%).

Cite This Study

Okoye et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953efe4 https://doi.org/10.18553/jmcp.2026.32.7.832

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