November 28, 2005Archives of Internal Medicine
Impact of Antidepressant Drug Adherence on Comorbid Medication Use and Resource Utilization
Why the study?
Does adherence to antidepressant medication improve comorbid medication adherence and reduce medical costs in patients with depression and chronic comorbid conditions (CAD, dyslipidemia, DM)?
Population
8,040 patients initiating antidepressant drug therapy with evidence of dyslipidemia, coronary artery…
Comparison
Adherence to antidepressant medication vs Nonadherence to antidepressant drug therapy
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Antidepressant adherence linked to better cardiometabolic adherence and lower costs; hypothesis-generating for causality and practice change pending RCTs.
Structured PICO
Does adherence to antidepressant medication improve comorbid medication adherence and reduce medical costs in patients with depression and chronic comorbid conditions (CAD, dyslipidemia, DM)?
P
Population
8,040 patients initiating antidepressant drug therapy with evidence of dyslipidemia, coronary artery disease (CAD), or both; diabetes mellitus (DM); or CAD/dyslipidemia and DM identified from a claims database.
I
Intervention
Adherence to antidepressant medication (measured by medication possession ratio during 180 days without a 15-day gap before 90 days of therapy)
C
Comparator
Nonadherence to antidepressant drug therapy
O
Outcome
Comorbid medication adherence (measured by medication possession ratio during 1 year) and medical costs (disease-specific and total)
Adherence to antidepressant therapy in patients with depression and cardiometabolic comorbidities is associated with significantly better adherence to medications for those comorbidities and lower total medical costs.
Cite This Study
Katon et al. (2005) studied this question.