Association of medication adherence and depression with the control of low-density lipoprotein cholesterol and blood pressure in patients at high cardiovascular risk
Why the study?
Many patients at high cardiovascular risk do not reach LDL-C and blood pressure targets, and depression is a frequent comorbidity that contributes to poor medication adherence.
Are medication adherence and depression associated with the control of LDL-C and blood pressure in patients at high cardiovascular risk?
Population
3,188 ambulatory patients with hypercholesterolemia, stable CAD, or both in Germany
Comparison
Adherence levels to lipid- and BP-lowering drugs and presence vs absence of depression
Design
Multicenter single-visit cross-sectional study
Authors
Discussion
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Member takes
Implication
High or moderate statin adherence improves LDL-C control; reinforces targeting adherence in high-risk patients.
Structured PICO
Are medication adherence and depression associated with the control of LDL-C and blood pressure in patients at high cardiovascular risk?
P
Population
3,188 ambulatory patients with hypercholesterolemia (39.8%), stable coronary artery disease (7.4%), or both (52.9%) in Germany.
I
Intervention
High or moderate adherence to lipid- and BP-lowering drugs (assessed by MMAS-8) and/or diagnosis of depression
C
Comparator
Low adherence to medications and/or absence of depression
O
Outcome
Control of LDL-C and BP (levels and guideline-recommended target achievement)surrogate
Low medication adherence and comorbid depression are significantly associated with poorer control of LDL-C and blood pressure in high-risk cardiovascular patients.
Cite This Study
Katzmann et al. (2018) studied this question.