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December 8, 2025Blood

Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis

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Authors

ANAdithya NagendranAVAnushree Venkatesh-MurthyMYMuhammad Yousuf

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Overview

Retrospective analysis shows higher in-hospital mortality in adults with sickle cell disease and cardiovascular issues, suggesting critical health implications.

Key Points

  • To evaluate the independent impact of cardiovascular comorbidities on in-hospital mortality among adults hospitalized for sickle cell crisis.
  • Retrospective analysis of adults hospitalized for sickle cell crisis in the U.S. (2016-2020)
  • Utilized National Inpatient Sample database
  • Performed univariable and multivariable Cox regression to identify predictors of in-hospital mortality
  • Analyzed 424,540 sickle cell disease patients hospitalized for crisis
  • Age and specific cardiovascular conditions increased in-hospital mortality
  • Systolic heart failure, atrial fibrillation, and ischemic stroke significantly associated with increased mortality

Cite This Study

Nagendran et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d53chttps://doi.org/10.1182/blood-2025-6223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A66-04 Inpatient Outcomes and Mortality of Congestive Heart Failure in Sickle Cell Disease: A Retrospective Nationwide Analysis2026
  2. 2Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis2026
  3. 3The Impact of Sickle Cell Disease on Acute Coronary Syndrome and PCI Outcomes: A Retrospective Observational Study2024 · 3 citations
  4. 4Clinical Outcomes of Sickle Cell Disease Patients With Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Nationwide Analysis2024
  5. 5Pulmonary hypertension as an independent predictor of mortality in hospitalized sickle cell disease patients: A national analysis of comorbidities and outcomes2025