What question did this study set out to answer?

This research aims to identify factors associated with outcomes and mortality in hospitalized SCD patients with cardiovascular and thromboembolic complications.

February 26, 2026Angiology

Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis

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Authors

HSHarsha SanakaCleveland Clinic CCChin-I Cheng EHElio HarounCleveland Clinic

Discussion

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Implication

Analysis assesses mortality predictors in hospitalized sickle cell patients with cardiovascular complications, suggesting improvements in care.

Key Points

This research aims to identify factors associated with outcomes and mortality in hospitalized SCD patients with cardiovascular and thromboembolic complications.
Analyzed national inpatient data from 2012-2021 using ICD-9 and -10 codes for CVTE complications in SCD patients.
Conducted mortality trend assessments with the Cochran-Armitage test.
Identified mortality predictors using multivariable logistic regression accounting for survey design.
Among 1,388,310 SCD-related hospitalizations, 441,820 involved CVTE complications.
In-hospital mortality was significantly higher for patients with CVTE complications (1.5% vs 0.3%).
Identified mortality predictors included Charlson comorbidity index, myocardial infarction, arrhythmias, and COVID-19.

Cite This Study

Sanaka et al. (2026) studied this question.

synapsesocial.com/papers/699fe3f995ddcd3a253e81ee https://doi.org/10.1177/00033197261418309

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February 26, 2026Angiology

Contemporary Trends, In-Hospital Outcomes, and Adverse Prognosticators of Sickle Cell Patients with Cardiovascular and Thromboembolic Complications: A National Database Analysis

View Full Paper

Ask AI

Bookmark

Authors

HSHarsha SanakaCleveland Clinic CCChin-I Cheng EHElio HarounCleveland Clinic

Discussion

Member takes

Implication

Analysis assesses mortality predictors in hospitalized sickle cell patients with cardiovascular complications, suggesting improvements in care.

Key Points

This research aims to identify factors associated with outcomes and mortality in hospitalized SCD patients with cardiovascular and thromboembolic complications.
Analyzed national inpatient data from 2012-2021 using ICD-9 and -10 codes for CVTE complications in SCD patients.
Conducted mortality trend assessments with the Cochran-Armitage test.
Identified mortality predictors using multivariable logistic regression accounting for survey design.
Among 1,388,310 SCD-related hospitalizations, 441,820 involved CVTE complications.
In-hospital mortality was significantly higher for patients with CVTE complications (1.5% vs 0.3%).
Identified mortality predictors included Charlson comorbidity index, myocardial infarction, arrhythmias, and COVID-19.

Cite This Study

Sanaka et al. (2026) studied this question.

synapsesocial.com/papers/699fe3f995ddcd3a253e81ee https://doi.org/10.1177/00033197261418309

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