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December 8, 2025BloodOpen Access

Association of obstructive sleep apnea with readmission and healthcare utilization in adults with sickle cell disease: A propensity-matched analysis of national readmission data

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Authors

RMRichard Mansour

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Overview

Retrospective analysis shows obstructive sleep apnea increases readmissions and healthcare costs in sickle cell disease patients, highlighting the need for effective screening.

Key Points

  • This research aimed to assess the link between obstructive sleep apnea and hospital readmissions in adults with sickle cell disease.
  • Conducted a retrospective cohort study using National Readmissions Database (2018-2022)
  • Included non-elective hospitalizations of adults with sickle cell disease, identified by ICD-10 codes
  • Performed 1:1 propensity score matching for demographic and clinical characteristics
  • Analyzed outcomes using risk ratios and logistic regression methodologies
  • Obstructive sleep apnea increased 30-day readmission rates by 8%, 60-day by 9%, and 90-day by 8%
  • Patients with OSA had longer hospital stays (6.8 vs 5.9 days) and higher charges per admission ($59,474 vs $51,027)
  • The economic burden associated with OSA was estimated at $400 million over five years

Cite This Study

Richard Mansour (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e53fhttps://doi.org/10.1182/blood-2025-2663
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