What question did this study set out to answer?

To assess the correlation of mean flow velocities by transcranial Doppler with MRA-defined cerebral vasculopathy in adults with sickle cell disease.

December 8, 2025BloodOpen Access

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

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To assess the correlation of mean flow velocities by transcranial Doppler with MRA-defined cerebral vasculopathy in adults with sickle cell disease.
Conducted a retrospective study of adults with sickle cell disease undergoing both TCD and MRA.
Measured mean flow velocities in middle, anterior, and posterior cerebral arteries using transcranial Doppler.
Compared flow velocities between patients with and without MRA-defined vasculopathy using independent samples t-tests.
187 patients included, with mean age 35 years; 56% were women.
TCD-measured mean flow velocities were significantly higher in patients with MRA-defined stenosis in the middle cerebral artery.
All but 3 patients with stenosis had TCD MFV ≥ 60 cm/s indicating a high negative predictive value for significant abnormalities.

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Implication

Retrospective study demonstrates transcranial Doppler correlates with MRA-defined vasculopathy in adults with sickle cell disease, suggesting a resource-efficient approach.

Cite This Study

Kazadi et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de05 https://doi.org/10.1182/blood-2025-4734

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Implication

Retrospective study demonstrates transcranial Doppler correlates with MRA-defined vasculopathy in adults with sickle cell disease, suggesting a resource-efficient approach.

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

Key Points

Discussion

Implication

Cite This Study

Standard transcranial doppler as a resource-efficient first step to screen for MRA-defined cerebral vasculopathy in adults with sickle cell disease

Key Points

Discussion

Implication

Cite This Study

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