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December 8, 2025BloodOpen Access

Pregnancy related complications and placenta pathology in pregnant women with sickle cell disease

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Authors

AAAbraham AttahEmory UniversityFRFuad El RassiEmory University

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Implication

Retrospective study reveals low hemoglobin during pregnancy increases risks of pre-eclampsia and fetal growth restriction in women with sickle cell disease, suggesting better management needed.

Key Points

  • This study aims to examine pregnancy complications and placental pathology in women with sickle cell disease.
  • Single center retrospective study of pregnant women with sickle cell disease
  • Analyzed demographics, hemoglobin levels, and SCD therapy pre-pregnancy and during pregnancy
  • Assessed post-partum maternal and fetal complications and placental morphology
  • Low hemoglobin levels during pregnancy were linked to higher incidents of pre-eclampsia and fetal growth restriction
  • Most common genotypes were Hb SS and Hb SC
  • 38 out of 48 examined placentas showed abnormalities related to maternal vascular malperfusion

Cite This Study

Attah et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de07https://doi.org/10.1182/blood-2025-4744
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Retrospective Analysis of Transfusions on Sickle Cell–Related Morbidity in Pregnancy2024
  2. 2Pregnancy Outcomes Among Women With Sickle Cell Disease in Bahrain: A Case-Control Study2024 · 2 citations
  3. 3Increased risk of venous thromboembolism and hypertensive disorders during pregnancy in sickle cell disease patients: A meta-analysis focused on actionable outcomes2025
  4. 4Maternal and Fetal Outcomes of Pregnancies Complicated by Sickle Cell Disease at a Tertiary Hospital in Northwestern Nigeria: A 10-Year Retrospective Cohort Study2026
  5. 5Maternal–fetal prognosis of major sickle cell disease in pregnant women at a university hospital in a low–middle-income country2025