What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

To assess long-term outcomes of adolescents and young adults with sickle cell disease receiving hydroxyurea therapy in Malawi.

December 8, 2025BloodOpen Access

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To assess long-term outcomes of adolescents and young adults with sickle cell disease receiving hydroxyurea therapy in Malawi.
Conducted a follow-up study on AYA aged ≥16 receiving care at Kamuzu Central Hospital.
Extracted data from electronic database on demographics, clinical outcomes, and laboratory parameters.
Analyzed outcomes including survival rates and treatment duration.
94% of patients were alive and receiving care at follow-up.
Mean age of patients receiving care was 18 years, with hydroxyurea use at 96%.
21% of patients had received a blood transfusion and 23% had been hospitalized for SCD-related complications.

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Follow-up study shows improved survival and clinical outcomes with hydroxyurea in adolescents and young adults with sickle cell disease.

Kambe Banda-Zgambo (2025) studied this question.

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