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December 8, 2025BloodOpen Access

Development and validation of a novel pathologically-based prognostic model for primary central nervous system lymphoma

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Authors

XHXinting HuZhejiang Sci-Tech University

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Implication

This analysis develops a prognostic model predicting overall survival in PCNSL patients, highlighting key risk factors and treatment implications.

Key Points

  • To develop and validate a novel prognostic model for overall survival in primary central nervous system lymphoma (PCNSL) patients.
  • Retrospective analysis of clinical data from 180 newly diagnosed PCNSL patients aged ≥18 years.
  • Primary endpoint was overall survival and secondary was progression-free survival.
  • Conducted univariable and multivariable cox regression analyses to identify predictors of overall survival.
  • Developed a prognostic model based on identified risk factors; validated it for calibration and clinical utility.
  • Developed model showed excellent discriminative ability with AUC values of 0.74 in the training set and 0.88 in the validation set.
  • Satisfactory calibration performance demonstrated close agreement between predicted probabilities and actual observations.
  • Decision curve analysis confirmed consistent net clinical benefit across a range of risk thresholds.

Cite This Study

Xinting Hu (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de13https://doi.org/10.1182/blood-2025-5446
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A novel prognostic model for primary central nervous system lymphoma incorporating clinico-laboratory parameters2025
  2. 2Evaluation of treatment regimens and prognostic factors in primary central nervous system lymphomas2025 · 1 citations
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  4. 4Construction of a prognostic model for new diffuse large B-cell lymphoma and research on risk factors for secondary central nervous system infiltration2025
  5. 5Prognostic Assessment in Patients With Primary Diffuse Large B‐Cell Lymphoma of the Central Nervous System Using MRI ‐Based Radiomics2024 · 7 citations