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December 8, 2025BloodOpen Access

Construction of a prognostic model for new diffuse large B-cell lymphoma and research on risk factors for secondary central nervous system infiltration

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Authors

SHShuling HouShanxi Medical UniversityJCJuya CuiShanxi Academy of Medical SciencesTWTao WangShanxi Medical University

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Overview

Prognostic model predicts overall survival in diffuse large B-cell lymphoma, suggesting P53 mutations and nomogram utility.

Key Points

  • The study aims to improve prognostic accuracy for diffuse large B-cell lymphoma (DLBCL) and assess risk factors for CNS infiltration.
  • Developed a prognostic model using 20 factors from 1364 DLBCL patients
  • Applied univariate and multivariate regression analyses on genetic markers
  • Utilized ROC curves and calibration methods to validate model stability.
  • Nomogram predicts overall survival with AUC values over 0.7 at multiple time points
  • POD6 identified as a major high-risk factor (HR = 5.13)
  • P53 mutations emerged as a key adverse prognostic factor.

Cite This Study

Hou et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e58chttps://doi.org/10.1182/blood-2025-5438
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