What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

Evaluate the safety and efficacy of teclistamab in patients with triple-class exposed multiple myeloma.

December 8, 2025Blood

Teclistamab in a large cohort of ~100 Asian patients with triple-class exposed multiple myeloma: Experience from trials and non-trial settings

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Authors

JYJun Ho YiSamsung Medical Center DYDok Hyun YoonUlsan College YSYang SongNingbo University

Discussion

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Implication

Clinical data reveals tec improves complete response and progression-free survival in Asian multiple myeloma patients, suggesting enhanced treatment options.

Key Points

Evaluate the safety and efficacy of teclistamab in patients with triple-class exposed multiple myeloma.
Analyzed data from Asian patients in trial and non-trial settings.
Cohorts included 52 patients from MajesTEC-1 and 47 patients from pre-approval access.
Efficacy monitored through overall response rate, complete response, and survival metrics.
In the trial cohort, ORR was 76.9% and complete response rate was 63.5%.
Median progression-free survival was 59.5% at 24 months.
The safety profile was consistent with known effects of BCMA bispecific antibodies.

Cite This Study

Yi et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de2f https://doi.org/10.1182/blood-2025-5815

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Implication

Clinical data reveals tec improves complete response and progression-free survival in Asian multiple myeloma patients, suggesting enhanced treatment options.

Teclistamab in a large cohort of ~100 Asian patients with triple-class exposed multiple myeloma: Experience from trials and non-trial settings

Discussion

Member takes

Implication

Key Points

Cite This Study

Teclistamab in a large cohort of ~100 Asian patients with triple-class exposed multiple myeloma: Experience from trials and non-trial settings

Discussion

Member takes

Implication

Key Points

Cite This Study

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