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December 8, 2025Blood

Measuring success by different rulers: Heterogeneity in definition of outcomes in immune thrombocytopenia trials

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Authors

DGDavid Gómez‐Almaguer

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Overview

Systematic review assesses adherence to IWG and ASH guidelines in ITP trials, revealing major compliance gaps.

Key Points

  • To evaluate adherence to outcome definitions in immune thrombocytopenia trials according to established guidelines.
  • Conducted a systematic search on ClinicalTrials.gov
  • Included phase 2/3 and phase 3 clinical trials
  • Focused on trials involving immune thrombocytopenia
  • Assessed compliance with IWG 2009 and ASH 2019 guidelines
  • Performed descriptive analysis using R.
  • 79 trials met inclusion criteria, mostly phase 3 (92.4%) and randomized (68.4%)
  • 41.8% of trials did not specify time from diagnosis; 82.3% lacked platelet count thresholds
  • Only 20.3% of primary outcomes adhered to guideline definitions
  • 78.3% of primary outcomes were platelet-related
  • Many trials used non-standard terminology for outcomes.

Cite This Study

David Gómez‐Almaguer (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236de9ahttps://doi.org/10.1182/blood-2025-3038
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Patient survey in immune thrombocytopenia (<scp>ITP</scp>): Identifying unmet needs related to treatment and disease control in patients living in the United States2025 · 2 citations
  2. 2Synopsis of the 2025 guideline for the diagnosis and management of adult primary immune thrombocytopenia2026
  3. 3Assessment of Clinical Course and Treatment Responses in Our Patients with Immune Thrombocytopenia2026
  4. 4Multicenter initiative to standardize management of pediatric immune thrombocytopenia improves adherence to guidelines2026 · 1 citations
  5. 5The holistic trial: A comprehensive evaluation of two second-line therapeutic approaches for immune thrombocytopenia (ITP) – a pragmatic randomized controlled trial2025