What question did this study set out to answer?

To assess the prevalence and incidence of idiopathic multicentric Castleman disease in Spain.

December 8, 2025Blood

Epidemiology and clinical characteristics of idiopathic multicentric castleman disease in Spain (ARCANA study): Prevalence cohort

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Observational study assessed prevalence and comorbid conditions in patients with iMCD in Spain, indicating low incidence and treatment outcomes.

To assess the prevalence and incidence of idiopathic multicentric Castleman disease in Spain.
Multicenter observational study enrolling patients from 20 centers across Spain.
Two cohorts: prevalence cohort (historical cases) and incidence cohort (newly diagnosed patients).
Data on demographics, clinical characteristics, and treatments were collected from patient records.
Prevalence of iMCD estimated at 0.50715 cases per 100,000 inhabitants.
35 patients met inclusion criteria; 30 from prevalence cohort and 5 from incidence cohort.
70% of patients had comorbid conditions, with hypertension and autoimmune disorders being the most common.

Ubieto et al. (2025) studied this question.

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Observational study assessed prevalence and comorbid conditions in patients with iMCD in Spain, indicating low incidence and treatment outcomes.