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December 8, 2025BloodOpen Access

A murine monoclonal antibody to integrin αIIbβ3 that inhibits protein disulfide isomerase binding to platelets and platelet aggregation

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Authors

LWLu WangWannan Medical CollegeJWJialing WangEast Tennessee State UniversityJLJihong LiSouth China Agricultural University

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Implication

Monoclonal antibody R21C11 demonstrates inhibition of fibrinogen binding and platelet activation, suggesting potential therapeutic roles.

Key Points

  • To investigate the effects of R21C11, a monoclonal antibody, on platelet activation and fibrinogen binding.
  • Platelets were activated with thrombin receptor peptides and exposed to R21C11 for analysis.
  • Platelet aggregation assays were conducted using washed platelets and platelet-rich plasma with various treatments.
  • Binding interactions were assessed using cryo-electron microscopy and flow cytometry.
  • R21C11 inhibited fibrinogen binding to activated platelets by 40%.
  • The antibody significantly reduced platelet activation in response to thrombin peptide.
  • Cryo-electron microscopy revealed R21C11 binding sites on αIIbβ3.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df11https://doi.org/10.1182/blood-2025-3016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A monoclonal antibody to platelet αIIbβ3 that inhibits protein disulfide isomerase binding and platelet aggregation2026
  2. 2Greater inhibition of platelet procoagulant activity by antibody‐derived glycoprotein IIb–IIIa inhibitors than by peptide and peptidomimetic inhibitors2001 · 16 citations
  3. 3Characterization of a Novel Function-Blocking Antibody Targeted Against the Platelet P2Y 1 Receptor2015 · 22 citations
  4. 4Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".1996 · 399 citations
  5. 5P2Y 12 Receptor Blockade Augments Glycoprotein IIb‐IIIa Antagonist Inhibition of Platelet Activation, Aggregation, and Procoagulant Activity2013 · 19 citations