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December 8, 2025Blood

Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd

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Authors

MZMeng ZhangXZXiangjun ZengYLYanjuan Liu

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Overview

Findings reveal thymic dysfunction prompts premature thymocyte release in acute graft-versus-host disease, suggesting a key role in tissue injury.

Key Points

  • To explore the role of thymic dysfunction in the emergence of pathogenic CD4⁺CD8⁺ T cells during acute graft-versus-host disease (aGVHD).
  • Utilized a murine aGVHD model with GFP-labeled donor cells
  • Measured thymic atrophy and thymocyte populations
  • Conducted single-cell RNA sequencing and spatial transcriptomic profiling
  • Compared peripheral DP T cells' characteristics with those from thymus and spleen.
  • Observed marked thymic atrophy and reduction in thymocyte numbers in aGVHD
  • Identified accumulation of peripheral CD4⁺CD8⁺ T cells in target organs
  • Peripheral DP T cells displayed high proliferation markers but minimal effector gene expression
  • Thymic DP cells had normal developmental markers, unlike splenic DP cells from aGVHD.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df17https://doi.org/10.1182/blood-2025-4240
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